Moderna has begun trials of a vaccine booster against Omicron

The American company Moderna announced on Wednesday that it had started clinical trials of a booster dose of a vaccine designed specifically against the Omicron variant of the coronavirus. These trials will be conducted on 600 adults.

Half of them have already received two doses of Moderna’s vaccine at least six months ago, the other half received not only these two initial doses, but also, at least three months ago, the booster dose already authorized.

The specific booster against Omicron will therefore be assessed both as a third or fourth dose.

Antibody persistence

The company also reported results on the effectiveness of the recall already authorized against Omicron. According to the company, six months after the booster injection, levels of neutralizing antibodies against Omicron were reduced six-fold from the peak seen 29 days after the sting, but remained detectable in all participants.

These data were obtained by studying the blood of 20 people who received the booster dosed at 50 micrograms, half as much as the first two injections. “We are reassured by the persistence of antibodies against Omicron six months after the currently authorized recall,” said Stéphane Bancel, the boss of Moderna, in a press release.

“However, given the long-term threat posed by immune evasion from Omicron, we are moving forward with our specific vaccine candidate recall against Omicron,” he added.

The Pfizer-BioNTech alliance also announced this week that it has started trials to test its own specific vaccine against Omicron. But Pfizer is evaluating its formula not only as a booster, but also for the initial round of injections, in previously unvaccinated people.

These two vaccines are based on the messenger RNA technique, which in particular makes it possible to update them relatively easily to follow the evolution of the mutations specific to the new variants.

ats, afp

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