Specialist doctors demand the elimination of two drugs used in Romania for the treatment of patients infected with COVID-19, because they were found to have side effects.
Thus, the specialists from Cochrane Romania claim that both Lopinavir – Ritonavir, with the trade name Kaletra, and Hydroxychloroquine, known as Plaquenil, have a “Increased number of side effects”, and the alleged benefits of treatment are missing, according to recently published studies.
”At best, Plaquenil may shorten the course of the disease. For those who have a mild form and stay at home, it does not prevent aggravation and hospitalization. For those who are serious, it does not prevent death. It does not prevent those who are in the hospital from aggravating and reaching intensive care and intubation. I wrote there, I don’t know which, of all those systematic syntheses, there were about 4 or 5 that had even found a higher mortality. All sorts of alarm signals have been sounded, especially by cardiologists, about some cardiovascular side effects.. ” – said Professor Cristian Băicuș, member of the Cochrane Romania advisory board and doctor at Colentina Hospital in Bucharest, in an interview given to the journalist Pro TV Liliana Curea, the producer of the show “Good doctor”.
He calls for the urgent elimination of these two drugs and the amendment of Order no. 487 / 23.03.2020 for the approval of the protocol for the treatment of SARS-VOC-2 virus infection.
hydroxychloroquine, known as Plaquenil, has been used in treatment protocols for COVID-19 worldwide, but since the beginning of the pandemic, randomized clinical trials have begun to show its effects on mortality and disease severity.
Specifically, following 17 systematic syntheses and 5 randomized clinical trials conducted between July and October 2020, no definitive evidence was found showing that Hydroxychloroquine or Plaquenil would have decreased mortality among patients, but – on the contrary – was noted an increase in mortality.”- it is shown in a communiqué of Cochrane Romania.
Professor Cristian Băicuș also warns that, given the lack of important beneficial effects for the patient, as well as the presence of undeniable side effects, administration is not recommended for patients with COVID-19.
“Hydroxychloroquine may reduce the duration of symptoms by a few days. For those not hospitalized, it does not reduce the risk of hospitalization “, says Prof. Dr. Cristian Băicuș, according to a statement.
Another argument made by the doctor is that hydroxychloroquine has disappeared from treatment protocols in many countries.
The same conclusion is reached in Lopinavir-Ritonavir-based therapy or Kaletra. Some observational studies performed on patients diagnosed with COVID-19 reported that treatment would shorten the duration of the disease, but at the same time other similar studies did not show benefits of therapy.
Thus, between January and October 2020, three randomized studies were identified that compare the effectiveness of Kaletra treatment with the standard one, ie without antiviral drugs. The latest study, published in the journal Lancet earlier this month, included about 1,600 patients, in whom no treatment benefits were identified.
Currently, the Cochrane specialists also say, according to order no. 487 of March 23, 2020, subsequently amended by Order no. 1,418 of 7 August 2020, the protocol for the treatment of SARS-CoV-2 virus infection includes Lopinavir and therapy with hydroxychloroquine.
“Given the absence of proven benefits for both Lopinavir-Ritonavir and Hydroxychloroquine, and the detection of a risk associated with an increased number of adverse effects, we consider it necessary to urgently amend the MS order and modify the therapeutic protocol.“- say the Romanian specialists.
In May, Donald Trump shocked by announcing that he was being treated with Hydroxychloroquine
In May, Donald Trump he was shocked to announce that he was being treated with Hydroxychloroquine, a drug used for malaria, but which he promoted, saying it would have positive results.
Trump told reporters that his personal doctor did not recommend taking the drug, but later turned to the White House official.
Subsequently, the World Health Organization decided to stop clinical trials with hydroxychloroquine as a potential treatment for hospitalized COVID-19 patients.
The reason: “hydroxychloroquine – when compared to the usual treatments of patients hospitalized for COVID-19 – does not result in a reduction in the mortality of these patients”.